Compositions and methods for treating heart failure

US6908923B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Fady Malik · Burlingame, US
• Adam Lewis Tomasi · San Francisco, US
• Bainian Feng · Foster City, US
• Erica Anne Kraynack · South San Francisco, US
• Kathleen Ann Elias · San Francisco, US
• Pu-Ping Lu · Foster City, US
• Whitney W. Smith · South San Francisco, US
• Xiangping Qian · Foster City, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Dec 20, 2002
• Grant date: Jun 21, 2005
• Expiry date: Mar 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain substituted benzamide derivatives of Formula I: selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.