Substituted imidazoles, their preparation and use

US6908926B1 · kind B1 · utility

Assignee

• Novo Nordisk A/S · DK

Inventors

• Florencio Zaragoza Dorwald · Rang Taché Est, DK
• Knud Erik Andersen
• Tine Krogh Jørgensen · Alte Poststraße, DK
• Bernd Peschke · Thisted, DK
• Birgitte Schjellerup Wulff · Avenue Madeleine, DK
• Ingrid Pettersson · Copenhagen, DK
• Klaus Rudolf · Warthausen, DE
• Dirk Stenkamp · Biberach, DE
• Rudolf Hurnaus · Großenhain, DE
• Stephan Muller · Warthausen, DE
• Bernd Krist · Wien, AT

Key dates

• Filing date: Apr 12, 2000
• Grant date: Jun 21, 2005
• Expiry date: Apr 12, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.