Patent · US Expired

Luminescent method of detecting soluble guanylate cyclase

US6913898B2 · kind B2 · utility

7Cited by

3References

1Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Ursula Schindler · Bad Soden, DE
Hartmut Strobel · Liederbach, DE
Peter Schindler · Rodgau, DE
Alexander Muelsch · Heidelberg, DE

Key dates

Filing date	Oct 10, 2002
Grant date	Jul 5, 2005
Priority date	—
Expiry date	Jun 12, 2023

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to methods for detecting a soluble guanylate cyclase whose heme iron is in the trivalent oxidation state, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase when the heme iron of at least part of this soluble guanylate cyclase is oxidized to the trivalent state and also to diagnostic aids or kits for detecting a soluble guanylate cyclase with trivalent heme iron. Further, the invention relates methods for detecting a soluble guanylate cyclase lacking a heme group, and to methods for finding chemical substances which stimulate the activity of a soluble guanylate cyclase lacking a heme group.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.