Human antibodies that bind human IL-12 and methods for producing

US6914128B1 · kind B1 · utility

Assignee

• Abbott GmbH & Co. KG · DE

Inventors

• Jochen G. Salfeld · North Grafton, US
• Michael Roguska · Cambridge, US
• Michael Paskind · Sterling, US
• Subhashis Banerjee · Hamden, US
• Daniel Edward Tracey · Harvard, US
• Michael White · Framingham, US
• Zehra Kaymakcalan · Westborough, US
• Boris Labkovsky · Framingham, US
• Paul Sakorafas · Newton, US
• Geertruida M. Veldman · Sudbury, US
• Amy Venturini · Lexington, US
• Angela Widom · Acton, US
• Stuart Friedrich · Cary, US
• Nicholas W. Warne · Andover, US
• Angela Myles · Andover, US
• John Gawain Elvin · Royston, GB
• Alexander Robert Duncan · Buckley, GB
• Elaine Joy Derbyshire · Royston, GB
• Sara Carmen · Cambridge, GB
• Thor Las Holtet · Rua W Três, DK
• Sarah Leila Du Fou · Hertford, GB
• Stephen J. Smith · Los Gatos, US

Key dates

• Filing date: Mar 24, 2000
• Grant date: Jul 5, 2005
• Expiry date: Mar 24, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Human antibodies, preferably recombinant human antibodies, that specifically bind to human interleukin-12 (hIL-12) are disclosed. Preferred antibodies have high affinity for hIL-12 and neutralize hIL-12 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, of the invention are useful for detecting hIL-12 and for inhibiting hIL-12 activity, e.g., in a human subject suffering from a disorder in which hIL-12 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies of the invention, and methods of synthesizing the recombinant human antibodies, are also encompassed by the invention.