Red blood cells loaded with S-nitrosothiol and uses therefor
US6916471B2 · kind B2 · utility
1Cited by
10References
30Claims
0Family size
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Key dates
| Filing date | Oct 23, 2001 |
| Grant date | Jul 12, 2005 |
| Priority date | — |
| Expiry date | Mar 10, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/721
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+ groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2 metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2 delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.