Heterocyclic acridone inhibitors of IMPDH enzyme

US6916809B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Ping Chen · San Diego, US
• T.G. Murali Dhar · Carbondale, US
• Edwin J. Iwanowicz · Cranbury, US
• Scott Hunter Watterson · Pennington, US
• Henry H. Gu · Bordentown, US
• Yufen Zhao · Pennington, US

Key dates

• Filing date: Dec 20, 2002
• Grant date: Jul 12, 2005
• Expiry date: Jan 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from ═O and ═S; W is —C(═O)—, —S(═O)—, or —S(O)2—; or W may be —CH2— if X is —C(═O)—; X is selected from —CH2—, —N(R4)—, and —O—, except that when W is —CH2—, X is —C(═O)—; Y is a bond or —C(R40)(R45)—; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X1, X2, X3, X4, X5, X6, X7, X8, X9, X10 and X11 are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification.