(1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase

US6916813B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Karnail Atwal · Newtown, US
• Gary J. Grover · Stockton, US
• Charles Z. Ding · San Mateo, US
• Philip D. Stein · Pennington, US
• John Lloyd · Yardley, US
• Saleem Ahmad · Wall, US
• Lawrnce G. Hamann · Cherry Hill, US
• David E. Green · Simpsonville, US
• Francis N. Ferrara · Bound Brook, US

Key dates

• Filing date: Dec 10, 2002
• Grant date: Jul 12, 2005
• Expiry date: Jan 1, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the formula (I), and pharmaceutically acceptable salts thereof, are useful for modulating mitochondrial F1F0 ATPase activity and treating ischemic conditions including myocardial infarction, congestive heart failure, and cardiac arrhythmias.