Flavone acetic acid analogs and methods of use thereof

US6916831B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Kuo-Hsiung Lee · Chapel Hill, US
• Yi Xia · South San Francisco, US
• Zheng-Yu Yang · Chapel Hill, US
• Kenneth F. Bastow · Chapel Hill, US
• Sheng-Chu Kuo · Taichung, TW

Key dates

• Filing date: Feb 24, 2003
• Grant date: Jul 12, 2005
• Expiry date: Feb 24, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are described having a structure according to Formula I or Formula II: wherein: X is selected from the group consisting of O, NH, and S; Y is selected from the group consisting of O and S; m is from 1 to 3; n is from 1 to 5; R1 and R3 are each independently selected from the group consisting of H, hydroxy, lower alky, lower alkoxy, halo, amino, aminoalkyl, nitro, heteroaryl, —OC(═O)R6, —O(C═O)OR6; and —O(C═O)N(R6)2; and R2 is side chain such as an acetic acid side chain, where p is O to 4, R5 is hydroxy, alkoxy or amino, and R6 is H or lower alkyl, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer.