Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors

US6919351B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Neville J. Anthony · Hatfield, US
• Robert Gomez · Perkasie, US
• Steven D. Young · Lansdale, US
• Melissa Egbertson · Ambler, US
• John S. Wai · Harleysville, US
• Jennifer J. Bennett · Lansdale, US

Key dates

• Filing date: Oct 9, 2001
• Grant date: Jul 19, 2005
• Expiry date: Oct 9, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, as compounds or pharmaceutically acceptable salts, or as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.