Compounds useful in reflux disease

US6919379B2 · kind B2 · utility

Assignee

• ASTRAZENECA AB · SE

Inventors

• Kevin Fitzpatrick · San Antonio, US
• William B. Geiss · Athens, US
• Anders Lehmann · Timrå, SE
• Gunnel E. Sunden · Göteborg, SE
• Sverker Von Unge

Key dates

• Filing date: Jun 4, 2002
• Grant date: Jul 19, 2005
• Expiry date: Jun 4, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro, or an oxo group; R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy