Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones

US6919451B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jiacheng Zhou · Shanghai, CN
• Lynette Oh · West Chester, US
• Philip Ma · Mountain View, US
• Hui Li · Santa Clara, US
• Pasquale N. Confalone · Wilmington, US

Key dates

• Filing date: Dec 3, 2002
• Grant date: Jul 19, 2005
• Expiry date: Dec 3, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds are useful as factor Xa inhibitors.