Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy

US6921531B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• Howard Hughes Medical Institute · US

Inventors

• Roger Briesewitz · Mountain View, US
• Gerald R. Crabtree · Woodside, US
• Thomas J. Wandless · Cambridge, US
• Gregory Thomas Ray · Stanford, US
• Kurt Vogel · Basel, CH

Key dates

• Filing date: Dec 21, 2001
• Grant date: Jul 26, 2005
• Expiry date: Mar 19, 2022

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/812
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Bifunctional molecules and methods for their use in the production of binary or tripartite complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. The molecular weight of the bifunctional molecule is less than about 5000 daltons. In the methods, an effective amount of the bifunctional molecule is administered to the host. In certain embodiments the bifunctional molecule binds to the presenter protein and a drug target to produce a tripartite complex, while in other embodiments the bifunctional molecule binds to either the presenter protein or the drug target, but not both, to produce a binary complex The subject methods and compositions find use in a variety of therapeutic applications.