Formulations and methods for providing prolonged local anesthesia

US6921541B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Mark Chasin · Manalapan, US
• Paul Goldenheim · Wilson, US
• Richard Sackler · Greenwich, US
• Joseph Tigner · New Milford, US
• Ronald M. Burch · Wilton, US

Key dates

• Filing date: Sep 9, 2002
• Grant date: Jul 26, 2005
• Expiry date: Sep 19, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/0024
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.