Patent · US Expired

Process for the preparation of amino acids by using coryneform bacteria with attenuated 1-phosphofructokinase activity

US6921651B2 · kind B2 · utility

11Cited by

1References

9Claims

0Family size

Assignee

Degussa AG · DE

Inventors

Mike Farwick · Essen, DE
Brigitte Bathe · Salzkotten, DE
Jennifer Brehme · Bielefeld, DE
Klaus Huthmacher · Gelnhausen, DE

Key dates

Filing date	Mar 18, 2002
Grant date	Jul 26, 2005
Priority date	—
Expiry date	Dec 18, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12P13/08
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a process for the preparation of L-amino acids. The process includes fermenting the coryneform bacteria producing the desired L-amino acid, in which at least the gene coding for 6-phosphofructokinase and/or the gene coding for 1-phosphofructokinase are/is attenuated, enriching the desired L-amino acid in the medium or in the cells of the bacteria, and isolating the L-amino acid. Optionally bacteria are employed in which, in addition, further genes of the biosynthetic pathway of the desired L-amino acid are enhanced, or bacteria are employed in which the metabolic pathways that diminish the formation of the desired L-amino acid are at least partly switched off.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.