Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives

US6921767B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Nagarajan R. Srinivasan · Chesterfield, US
• Ish Khanna · Vernon Hills, US
• Michael Clare · Skokie, US
• Alan F. Gasiecki · Vernon Hills, US
• Thomas E. Rogers · Ballwin, US
• Barbara Chen · Braintree, US
• Mark Russell · Skokie, US
• Hwang-Fun Lu · Ballwin, US
• Yu Yi · Skokie, US
• Renee Huff · Paddy Lane, US
• Bipinchandra N. Desai · Vernon Hills, US
• Balekudru Devadas · Chesterfield, US
• Mihir Dineshkumar Parikh · Davisville, US
• Thomas D. Penning · Elmhurst, US

Key dates

• Filing date: Dec 20, 2002
• Grant date: Jul 26, 2005
• Expiry date: Dec 20, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.