Bioactive coating composition and methods
US6921811B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2001 |
| Grant date | Jul 26, 2005 |
| Priority date | — |
| Expiry date | Dec 8, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/802
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention provides a bioactive coating composition, method and devices for bodily fluid-contacting surfaces. The coating comprises a complex of Formula II: wherein R1 is an C1-18alkyl or C6-32aryl group, each R2 is independently selected from the group consisting of C1-18alkyl and C6-32aryl, R3 is N or O, n is a number from 1 to 10, and x in a number from 1 to about 30, directly bound to a heparin-activity molecule via covalent bonding, with one or more bioactive molecules bound to the heparin-activity molecule. The bioactive molecule may be an adhesive molecule such as fibronectin, a growth factor such as basic fibroblast growth factor, or any other bioactive molecule that binds, by any mechanism, to a heparin-activity molecule
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.