Enantioselective reformatsky process for preparing optically active alcohols, amines and derivatives thereof

US6924386B2 · kind B2 · utility

Assignee

• Consortium für elektrochemische Industrie GmbH · DE

Inventors

• Klas Sorger · Hersbruck, DE
• Hermann Petersen · Burghausen, DE
• Jürgen Stohrer · Pullach, DE

Key dates

• Filing date: Aug 12, 2003
• Grant date: Aug 2, 2005
• Expiry date: Jan 14, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process is provided for preparing optically active alcohols, amines and derivatives thereof by reacting aldehydes or imines at a temperature of less than 15° C. in the presence of a chiral, enantiomerically pure auxiliary with an organozinc halide which is obtained from zinc and a reactive halogen compound, and water, acid or base, or an alkylating, arylating, acylating or silylating reagent is subsequently added.