Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them

US6924392B2 · kind B2 · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Stefan Peukert · Frankfurt am Main, DE
• Joachim Brendel · Bad Vilbel, DE
• Horst Hemmerle · Lorsch, DE
• Heinz-Werner Kleemann · Bischofsheim, DE

Key dates

• Filing date: Jun 4, 2003
• Grant date: Aug 2, 2005
• Expiry date: Jun 4, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/82
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Ortho, meta-substituted bisaryl compounds, processes for their preparation, their use as medicaments, and pharmaceutical preparations including their use as antiarrhythmic active compounds, for example, for the treatment and prophylaxis of atrial arrhythmias, e.g. atrial fibrillation (AF) or atrial flutters. Compounds of the invention include compounds of the formula I