Group (VII) transition-metal complexes with multidentate aminopolycarboxylate ligands and a kit for producing them
US6926883B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2000 |
| Grant date | Aug 9, 2005 |
| Priority date | — |
| Expiry date | Jun 28, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/0497
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to novel aminocarboxylate ligands that are suitable for complexing with a radionuclide, and are useful as imaging agents for diagnostic purposes. In accordance with the present invention, a method of preparing a compound of formula (I): fac-[M(CO)3(OH2)3]+, wherein M is Mn, 99mTc, 186Re or 188Re, involves reacting a metal in permetallate form with carbon monoxide and a reducing agent, wherein a mixture of a basic borate buffer and a reducing agent soluble in water but not substantially decomposed by water is solved in a water containing solvent system containing a solution of the metal in permanganate, pertechnetate or perrhenate form in the presence of carbon monoxide. The compound of formula (I) can be reacted with a ligand Lx to form a compound of formula (II): fac-[M(CO)3(X)2L1]n, wherein M is as defined above Lx is a multidentate ligand, and n is a charge of the ligand Lx increased with one + charge. The invention also is directed to novel compounds, and kits for carrying out the disclosed methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.