Composition exhibiting a von willebrand factor (vWF) protease activity comprising a polypeptide chain with the amino acid sequence AAGGILHLELLV

US6926894B2 · kind B2 · utility

Assignee

• Baxter Aktiengesellschaft · AT

Inventors

• Bernhard Laemmle · Bolligen, CH
• Helena Elisabeth Gerritsen · Boswil, CH
• Miha Furlan · Bern, CH
• Peter Turecek · Klosterneuburg, AT
• Hans-Peter Schwarz · Wien, AT
• Friedrich Scheiflinger · Wien, AT
• Gerhard Antoine · Groß-Enzersdorf, AT
• Randolf Kerschbaumer · Klosterneuburg, AT
• Luigina Tagliavacca · Milano, IT
• Klaus Zimmermann · Wien, AT

Key dates

• Filing date: Apr 12, 2001
• Grant date: Aug 9, 2005
• Expiry date: Oct 1, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y304/24087
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to vWF cleaving entities having a molecular weight of 180 kD, 170 kD, 160 kD, 120 kD or 110 kD and an N-terminal amino acid sequence of AAGGILHLELLV (SEQ ID NO: 1), vWF cleaving complexes and methods for their production.