Design and synthesis of renal dipeptidase inhibitors

US6927212B2 · kind B2 · utility

Assignee

• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• Saeed R. Khan · Owings Mills, US
• Bert Vogelstein · Baltimore, US
• Kenneth W. Kinzler · Baltimore, US
• Hallur Gurulingappa · Baltimore, US
• Phillip Buckhaults · Columbia, US

Key dates

• Filing date: Jul 28, 2003
• Grant date: Aug 9, 2005
• Expiry date: Jul 28, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.