Methods for evaluating the ability to metabolize pharmaceuticals
US6929912B2 · kind B2 · utility
0Cited by
8References
15Claims
0Family size
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Key dates
| Filing date | Feb 26, 2002 |
| Grant date | Aug 16, 2005 |
| Priority date | — |
| Expiry date | Feb 26, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.