Method and system for molecular array scanner calibration

US6929951B2 · kind B2 · utility

Assignee

• AGILENT TECHNOLOGIES, INC. · US

Inventors

• John Corson · Stanford, US
• Andreas Dorsel · Menlo Park, US
• Russell Parker · San Jose, US
• Andre Chow · London, GB

Key dates

• Filing date: Feb 28, 2002
• Grant date: Aug 16, 2005
• Expiry date: Aug 1, 2023

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A method and system for calibrating molecular arrays to a reference molecular array, and for subsequently calibrating the molecular arrays to maintain a constant signal-intensity-to-label-concentration ratio. In the first step of the two-step calibration method, a reference array coated with the fluorophore or chromophore used to label probe molecules is employed, while in the second step of the two-step method, a reference array coated with a stable dye is employed.