Ig fractions having immunomodulatory activity
US6932969B1 · kind B1 · utility
12Cited by
0References
13Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 7, 2000 |
| Grant date | Aug 23, 2005 |
| Priority date | — |
| Expiry date | Dec 1, 2020 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/868
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a method for preparing Ig fractions from human polyvalent intravenous Immunoglobulins (IV Ig) which are in particular likely to be responsible for the immunomodulatory effect observed during the treatment of certain autoimmune diseases. The invention concerns Ig fractions having reactivity to IgM, IgG F(ab′)2 or DNP hapten and no or little reactivity to non-self antigens, that is Ig fractions which have idiotypic interactions among themselves (connected fraction) or which include natural antibodies reacting with the DNP hapten. Said fractions exhibit a polyreactivity to specific autoantigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.