Patent · US Expired

Substrate for PP2C

US6933127B2 · kind B2 · utility

0Cited by

0References

8Claims

0Family size

Assignee

EUCRO EUROPEAN CONTRACT RESEARCH GMBH & CO. KG · DE

Inventors

Josef Krieglstein · Dömitz, DE
Susanne Klumpp · Marburg, DE

Key dates

Filing date	Jul 3, 2002
Grant date	Aug 23, 2005
Priority date	—
Expiry date	Aug 28, 2022

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/16
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to a combination of a protein phosphatase type 2C as an enzyme and a phospho-BAD as substrate. The protein BAD is dephosphorylated in position Ser155. Furthermore, the combination is used in an in vitro screening for ligands which modulate protein phosphatase type 2C, comprising the steps: incubating the protein phosphatase type 2C in combination with the substrate phospho-BAD and the ligand of the assay and detecting the decrease in phospho-BAD and/or the increase in phosphate and/or BAD. Therefore, new drugs for the treatment apoptosis may be found.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.