Heteroarylalkanoic acids as integrin receptor antagonists

US6933304B2 · kind B2 · utility

Assignee

• Pharmacia Corporation · SE

Inventors

• Srinivasan Nagarajan · Arlington Heights, US
• Ish Khanna · Vernon Hills, US
• Michael B. Tollefson · Dardenne Prairie, US
• Scott Mohler · Chicago, US
• Barbara Chen · Braintree, US
• Mark Russell · Skokie, US
• Balekudru Devadas · Chesterfield, US
• Thomas D. Penning · Elmhurst, US
• Lori A. Schretzman · Gurnee, US
• Dale P. Spangler · Deerfield, US
• Mark Laurence Boys · Lyons, US
• Nizal Chandrakumar · North Grafton, US
• Hung-Fun Lu · Manchester, US

Key dates

• Filing date: Jun 15, 2001
• Grant date: Aug 23, 2005
• Expiry date: Jan 14, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the αVβ3 and/or the αVβ5 integrin without significantly antagonizing the IIb/IIIa or αVβ6 integrin.