Autoinducer molecule

US6936447B1 · kind B1 · utility

Assignees

• University of Iowa Research Foundation · US
• University of Rochester · US
• Ithaca College · US

Inventors

• James Pearson · Cambridge, US
• Kendall M. Gray · Iowa City, US
• Luciano Passador · Rochester, US
• Kenneth Tucker · Germantown, US
• Anatol Eberhard · Brooktondale, US
• Barbara H. Iglewski · Fairport, US
• Everett P. Greenberg · Iowa City, US

Key dates

• Filing date: Apr 3, 2000
• Grant date: Aug 30, 2005
• Expiry date: Apr 3, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/875
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Autoinducer molecules, e.g., N-(3-oxododecanoyl)homoserine lactone, for Pseudomonas aeruginosa are described. The molecules regulate gene expression in the bacterium. Therapeutic compositions and therapeutic methods involving analogs and/or inhibitors of the autoinducer molecules also are described. The molecules are useful for treating or preventing infection by Pseudomonas aeruginosa.