Patent · US Expired

Targeted chromosomal genomic alterations with modified single stranded oligonucleotides

US6936467B2 · kind B2 · utility

125Cited by

7References

129Claims

0Family size

Assignee

University Of Delaware · US

Inventors

Eric B. Kmiec · Malvern, US
Howard Gamper · Philadelphia, US
Michael Rice · Newtown, US

Key dates

Filing date	Mar 27, 2001
Grant date	Aug 30, 2005
Priority date	—
Expiry date	Mar 27, 2021

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Presented are methods and compositions for targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. The oligonucleotides of the invention have at least one modified nuclease-resistant terminal region comprising phosphorothioate linkages, LNA analogs or 2′-O-Me base analogs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.