Median filter for liquid chromatography-mass spectrometry data
US6936814B2 · kind B2 · utility
8Cited by
33References
10Claims
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Key dates
| Filing date | Sep 7, 2004 |
| Grant date | Aug 30, 2005 |
| Priority date | — |
| Expiry date | Sep 7, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/8641
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
High-intensity, spiked noise is reduced in chromatography-mass spectrometry data by applying a nonlinear filter such as a moving median filter to the data. The filter is applied to individual mass chromatograms, plots of ion abundance versus retention time for each detected mass-to-charge ratio, and the filtered chromatograms are combined to form a filtered total ion current chromatogram. Standard linear filters are not effective for reducing noise in liquid chromatography-mass spectrometry (LC-MS) data because they assume a normal distribution of noise. LC-MS noise, however, is not normally distributed.
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