Method for transferring nucleic acid into striated muscles
US6939862B2 · kind B2 · utility
49Cited by
65References
30Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Nov 7, 2001 |
| Grant date | Sep 6, 2005 |
| Priority date | — |
| Expiry date | Jun 8, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method of transferring in vivo a molecule into a striated muscle cell. More specifically, a method of the invention comprises contacting in vivo a striated muscle cell with a molecule, and electrically stimulating the muscle cell with one or more unipolar pulses of an electric field intensity ranging from 1 to 800 V/cm2. In one embodiment, the molecule is a nucleic acid encoding a protein of interest. For example, the invention provides methods of promoting angiogenesis and hemostasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.