Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
US6942802B2 · kind B2 · utility
6Cited by
6References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 5, 2002 |
| Grant date | Sep 13, 2005 |
| Priority date | — |
| Expiry date | Jun 20, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/245
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to the purification of polypeptides and the removal of endotoxin via immobilized metal affinity chromatography (IMAC). More specifically, the invention relates to methods for removing bacterial endotoxin in a protein solution. In specific embodiments, the invention relates to the elimination of endotoxin from Moraxella catarrhalis outer membrane proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.