Red blood cells covalently bound with polymers
US6942859B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 5, 2001 |
| Grant date | Sep 13, 2005 |
| Priority date | — |
| Expiry date | Nov 5, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K35/18
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Living cells modified at their surface with specially selected polymers are disclosed. A simple method to covalently attach specially selected PEG derivatives to the surface of RBC in aqueous media under mild conditions is a preferred example. The selected PEG-modification dramatically reduced aggregation and low shear viscosity of RBC resuspended in autologous plasma, and inhibited RBC agglutination by blood group-specific antibodies. The morphology and deformability of the PEG-treated cells were unaltered. The PEG coating of the RBC surface is applicable to the treatment of a variety of diseases characterized by vaso-occlusion or impaired blood flow, e.g., myocardial infarction, shock, and sickle cell disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.