Malaria immunogen and vaccine
US6942866B2 · kind B2 · utility
22Cited by
7References
50Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Aug 15, 2001 |
| Grant date | Sep 13, 2005 |
| Priority date | — |
| Expiry date | Aug 15, 2021 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the HBc immunogenic loop sequence. The chimer preferably contains a malaria-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.