Immunoassays for determining vitamin b12, and reagents and kits therefor
US6942977B1 · kind B1 · utility
3Cited by
12References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 28, 1993 |
| Grant date | Sep 13, 2005 |
| Priority date | — |
| Expiry date | May 28, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/32
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are described for the development of monoclonal antibodies to intrinsic factor and the application of said antibodies in the development of B12 immunoassays. In particular, antibodies are described that are capable of binding to intrinsic factor only in the absence of vitamin B12, and that are released from binding in the presence, and upon the binding, of vitamin B12 to intrinsic factor. Assays may be formatted such that either antibody or intrinsic factor is immobilized or labeled.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.