Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function
US6944486B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2003 |
| Grant date | Sep 13, 2005 |
| Priority date | — |
| Expiry date | Aug 30, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N21/35
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced into the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.