Anti-fungal pharmaceutical compositions comprising an active ingredient prepared from Zingiber officinale
US6946153B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 14, 2003 |
| Grant date | Sep 20, 2005 |
| Priority date | — |
| Expiry date | Apr 2, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K36/9066
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating a patient suffering a disease associated with Trichophyton mentagrophytes or Pityrosporum ovale by applying topically an anti-fungal pharmaceutical composition which is prepared from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.