Production of functional proteins: balance of shear stress and gravity

US6946246B1 · kind B1 · utility

Assignee

• The United States of America as represented by the Administrator of the National Aeronautics and Space Administration · US

Inventors

• Thomas J. Goodwin · Friendswood, US
• Timothy Grant Hammond · New Orleans, US
• James Howard Kaysen · New Orleans, US

Key dates

• Filing date: Mar 21, 2000
• Grant date: Sep 20, 2005
• Expiry date: Mar 21, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2510/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides for a method of culturing cells and inducing the expression of at least one gene in the cell culture. The method provides for contacting the cell with a transcription factor decoy oligonucleotide sequence directed against a nucleotide sequence encoding a shear stress response element.