Cell regulatory genes, encoded products, and uses related thereto

US6946256B1 · kind B1 · utility

Assignees

• President and Fellows of Harvard College · US
• The Brigham and Women's Hospital, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Frank McKeon · Boston, US
• Annie Yang · La Mirada, US
• Massimo Loda · Belmont, US
• Sabina Signorretti · Brookline, US
• Christopher Crum · Brookline, US

Key dates

• Filing date: Mar 29, 2000
• Grant date: Sep 20, 2005
• Expiry date: Mar 29, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This application describes the cloning of p63, a gene at chromosome 3q27-29, that bears homology to the tumor suppressor p53. The p63 gene encodes at least six different isotypes. p63 was detected in a variety of human and mouse tissue and demonstrates remarkably divergent activities, such as the ability to transactivate p53 reporter genes and induce apoptosis. Isotopes of p63 lacking a transactivation domain act as dominant negatives towards the transactivation by p53 and p63.