Efficient methods for producing anti-microbial cationic peptides in host cells
US6946261B1 · kind B1 · utility
1Cited by
11References
29Claims
0Family size
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Key dates
| Filing date | Nov 19, 1999 |
| Grant date | Sep 20, 2005 |
| Priority date | — |
| Expiry date | Nov 19, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/50
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Endogenously produced cationic antimicrobial peptides are ubiquitous components of host defenses in mammals, birds, amphibia, insects, and plants. Cationic peptides are also effective when administered as therapeutic agents. A practical drawback in cationic peptide therapy, however, is the cost of producing the agents. The methods described herein provide a means to efficiently produce cationic peptides from recombinant host cells. These recombinantly-produced cationic peptides can be rapidly purified from host cell proteins using anion exchange chromatography.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.