Immunosuppressive effects of pteridine derivatives

US6946465B2 · kind B2 · utility

Assignee

• 4 AZA Bioscience NV · BE

Inventors

• Mark Waer · Heverlee, BE
• Piet Herdewijn · Heverlee, BE
• Wolfgang Pfleiderer · Konstanz, DE

Key dates

• Filing date: May 23, 2003
• Grant date: Sep 20, 2005
• Expiry date: May 23, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, being represented by the general formula (I). are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.