Human antibodies against eotaxin

US6946546B2 · kind B2 · utility

Assignee

• CAMBRIDGE ANTIBODY TECHNOLOGY LIMITED · GB

Inventors

• Tristan Vaughan · Cambridge, GB
• Alison J. Wilton · Cambridge, GB
• Stephen J. Smith · Los Gatos, US
• Sarah Helen Main · Royston, GB

Key dates

• Filing date: Mar 2, 2001
• Grant date: Sep 20, 2005
• Expiry date: Apr 2, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The antibody VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT-213. One or more complementarity determining regions (CDRs) of the CAT-212/-213 VH and/or VL domains, especially VH CDR3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralizing eotaxin, including methods of treatment of the human or animal body by therapy.