Nucleic acid encoding a modified threonine deaminase and methods of use
US6946588B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Aug 30, 2001 |
| Grant date | Sep 20, 2005 |
| Priority date | — |
| Expiry date | Nov 16, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/625
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Nucleic acid sequences, vectors, recombinant host cells, transgenic plants, and methods for their preparation are disclosed. The nucleic acid sequences encode threonine deaminase proteins that catalyze the conversion of threonine to α-ketobutyrate. One or both of the amino acids at positions 447 and 481 of the encoded proteins can be selected from groups of particular amino acids. For example, the amino acid at position 447 can be alanine, isoleucine, valine, phenylalanine, tryptophan, or methionine. The amino acid at position 481 can be alanine, isoleucine, proline, phenylalanine, tryptophan, or methionine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.