Multiplex analysis using membrane-bound sensitizers
US6949347B2 · kind B2 · utility
37Cited by
58References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 4, 2003 |
| Grant date | Sep 27, 2005 |
| Priority date | — |
| Expiry date | Jul 19, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/10
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tags specifically bind to selected membrane-associated analytes, after which the molecular tags are released upon activation of cleavage moieties, or sensitizers, anchored in the same membrane as the membrane-associated analytes. The released molecular tags are then identified by their distinct separation and detection characteristics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.