Methods related to immunostimulatory nucleic acid-induced interferon
US6949520B1 · kind B1 · utility
110Cited by
20References
89Claims
0Family size
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Key dates
| Filing date | Sep 27, 2000 |
| Grant date | Sep 27, 2005 |
| Priority date | — |
| Expiry date | Mar 13, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/23
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-α treatment-related side effects. In addition, methods are provided for supporting the survival and for activating natural interferon producing cells (IPCs) in vitro without exogenous IL-3 or GM-CSF. The invention is based on the discovery that certain CpG and non-CpG ISNAs promote survival and stimulation of IPCs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.