Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
US6949559B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 7, 2003 |
| Grant date | Sep 27, 2005 |
| Priority date | — |
| Expiry date | Jan 1, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The compounds of the present invention are 2,6,9-trisubstituted purine derivatives which are inhibitors of cyclin/cdk complexes. The compounds of the current invention also are potent inhibitors of human cellular proliferation. As such, the compounds of the present invention constitute pharmaceutical compositions with a pharmaceutically acceptable carrier. Such compounds are useful in treating a disorder mediated by elevated levels of cell proliferation in a mammal compared to a healthy mammal by administering to such mammal an effective amount of the compound. Examples of the compounds of the present invention are represented by the following chemical structures: with X, Y, D, Q, V, A, R1, R2, R3, R4, and n1 defined herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.