Heterocyclic compounds as ligands of the GABAA receptor

US6949562B2 · kind B2 · utility

Assignees

• Neurogen Corporation · US
• PFIZER INC. · US

Inventors

• Daniel Yohannes · Winston-Salem, US
• George D. Maynard · Clinton, US
• Jun Yuan · Guilford, US
• Linghong Xie · Guilford, US
• Kyungae Lee · Newton, US
• Manuka Ghosh · Madison, US
• George P. Luke · Clinton, US
• Xiaojun Liu · Nanhu, CN
• Arthur Nagal · Gales Ferry, US
• Lawrence Vincent · Moosup, US
• Kevin S. Currie · North Branford, US
• Zhe-Quing Wang · East Haven, US

Key dates

• Filing date: Sep 23, 2003
• Grant date: Sep 27, 2005
• Expiry date: Sep 23, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.