Microprecipitation method for preparing submicron suspensions
US6951656B2 · kind B2 · utility
2Cited by
89References
84Claims
0Family size
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Key dates
| Filing date | Sep 17, 2001 |
| Grant date | Oct 4, 2005 |
| Priority date | — |
| Expiry date | Sep 17, 2021 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1688
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of less than about 2 μm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.