Coumarin derivatives with COMT inhibiting activity

US6951870B2 · kind B2 · utility

Assignee

• ORION CORPORATION · FI

Inventors

• Jarmo Pystynen · Espoo, FI
• Martti Ovaska · Espoo, FI
• Jukka Vidgren · Helsinki, FI
• Timo Lotta · Vantaa, FI
• Marjo Yliperttula-Ikonen · Espoo, FI

Key dates

• Filing date: Jun 28, 2001
• Grant date: Oct 4, 2005
• Expiry date: Jun 28, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D311/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I′wherein the two —OH substituents in the phenyl moiety are in a position ortho to one another and R1 in a position ortho to one of the hydroxy groups; and X, R1 to R6 are as defined in disclosure. The compounds exhibit COMT enzyme inhibiting activity, so are useful as COMT inhibitors.