Production of imidazole derivatives and novel intermediates of the derivatives
US6951944B2 · kind B2 · utility
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Key dates
| Filing date | Feb 18, 2003 |
| Grant date | Oct 4, 2005 |
| Priority date | — |
| Expiry date | Feb 18, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improvement in the production of imidazole derivatives including histamine H3 agonist immepip and histamine H3 antagonist VUF4929. Desired imidazole derivatives can be easily obtained in high yield by using novel intermediates represented by the general formula (I): (I) wherein R1 is an amino-protecting group; R2 and R3 are each independently hydrogen, lower alkyl, or hydroxylated lower alkyl; R4 is lower alkyl, halogenated lower alkyl, or substituted or unsubstituted phenyl; and A is C1-3 alkylene
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