Tumor selective and biodegradable polyphosphazene-platinum(II) conjugate antitumor agent, and preparation method thereof
US6951953B2 · kind B2 · utility
1Cited by
3References
10Claims
0Family size
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Key dates
| Filing date | Jan 7, 2004 |
| Grant date | Oct 4, 2005 |
| Priority date | — |
| Expiry date | Jan 7, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a new class of a polyphosphazene-platinum(II) conjugate antitumor agent having high tumor tissue selectivity due to its enhanced permeability and retention effect to tumor tissues, and a preparation method thereof: wherein x represents the number of the ethylene oxide repeating unit and is 7, 12 or 16; y is 0, 1 or 2; z represents molar content of polyethylene glycol in the range of 0.5-1.5; n represents degree of polymerization of polyphosphazene in the range of 30-100; and A-A represents a diamine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.